The introduction of medicine, according to Cherokee Legend.  Excerpt from "Legends of America", by Kathy Weiser:

The Old Ones say that at one time all of Creation spoke the same language. The plants could communicate with the finned ones, the four-leggeds could speak with the trees, the stones could talk with the wind, and even the most dependent, most pitiful part of creation, the two-leggeds, or as we have come to call ourselves, the humans, could also speak with the other parts of creation. All existed in harmony. The plants, the animals, and the elements of the Four Directions (all existence) all knew that if the two leggeds were to survive, they would need help.

The animals gave of themselves, willingly sacrificing so that the humans could have food. They knew that their skins were much better suited to survival than that of the humans, so they allowed their skins to be taken and used for clothing and shelter. The Finned ones, The Fliers, and the Crawlers also allowed themselves to be used by the humans, to ensure their survival.

The Plant people, the Standing people (trees), and the Stone People (rocks) freely gave of themselves so that the humans had what they needed for food, clothing, and shelter. An agreement was forged that the two leggeds would ask permission for these gifts, give thanks for the sacrifice, and take no more than they needed. And so, it was good.

But then, the two-leggeds started growing in numbers and began to feel themselves more important than the rest of creation. They began to believe that the Web of Life revolved around them, ignoring the fact that they were just one small part of the Circle. The two leggeds began to kill without asking for permission. They began to take more than they needed. They ceased to give thanks. All parts of the agreement were broken.

The plants were distressed and said to the animals, “They wrong us, too. They dig us up, trample us, burn us out, and don’t even listen when we try to tell them what we can do to help them. Yet, we feel compassion for the two leggeds. Man struggles to realize his place in the web of creation and he cannot learn if he is wiped out by disease. Man needs our help, so for every disease you animals bring to them, we, the Plant People will give them a cure. All the two leggeds have to do is ‘ listen’ when we talk to them.”

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